Mouse Pancreatic Tumor Model Independent of Tumor Suppressor Gene Inactivation
نویسندگان
چکیده
منابع مشابه
Evolutionary dynamics of tumor suppressor gene inactivation.
Tumor suppressor genes (TSGs) are important gatekeepers that protect against somatic evolution of cancer. Losing both alleles of a TSG in a single cell represents a step toward cancer. We study how the kinetics of TSG inactivation depends on the population size of cells and the mutation rates for the first and second hit. We calculate the probability as function of time that at least one cell h...
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ژورنال
عنوان ژورنال: Pancreas
سال: 2018
ISSN: 1536-4828,0885-3177
DOI: 10.1097/mpa.0000000000001041